![]() The antidote is a piece of a protein that sticks to one arm of Pradaxa's molecule. Thrombin is key to blood clotting because it breaks a protein called fibrinogen into smaller fragments that glue platelets together, allowing a blood clot to form. Pradaxa works by stopping the action of the enzyme thrombin. Since rearranging the solar system isn’t an option, I’m going to have to get to work now.By clicking Sign up, you agree to our privacy policy. As they say, it’s best to use a new drug within the first 6 months of approval…while it still has no side effects. But there are 3.2 million patients up for grabs, so even a small slice of that pie isn’t bad. It is a protease inhibitor, and thus follows the 2 previously approved drugs in that category, Incivek and Victrelis. Johnson & Johnson received FDA approval for their new drug for Hepatitis C, Olysio. With a Grain of SaltĮver wondered what the difference was between Table Salt and Sea Salt? Here is a quick answer: By the way, I’m available as a consultant on this project…. This could be done and would, in my opinion, revolutionize prescribing practices in the U.S. Imagine a system that immediately alerted a prescriber that their drug selection required prior authorization, or exceeded the quantity limits imposed by the plan. Attention entrepreneurs! If you are looking for an idea…here is one to think about capitalizing on. The authors are talking about the lack of adequate integration of patient formulary data into e-prescribing software. Having spent 7 years doing formulary analysis and research, this article caught my eye. An antidote appears to be in development that would effectively stop the bleeding in emergency situations: Is it on Formulary? īut that concern may soon be put to rest. This was a serious concern, leading to pradaxa lawsuits over the maufacturer’s failure to warn patients of this possibility. However, a concern with Pradaxa has been the lack of an adequate antidote to reverse the blood-thinning effects if necessary. Pradaxa is easier, albeit much more expensive. But patients on warfarin require regular blood tests and must abide by certain dietary restrictions. It’s indicated for patients who might otherwise be candidates for warfarin. Pradaxa is a blood thinner approved in 2010 to help prevent strokes. The generic is cheap as salt (see more on salt below!). The insurance then pays the pharmacy the absurdly large amount for hydrocodone/acetaminophen, and AbbVie reimburses the health plan. But if you have insurance, you may get it for cheap. Don’t expect it on the Wal-Mart $4 list anytime soon. It still costs an absurd amount of money if you happen to pay cash for it. What’s with this “generic” status? For those who care to know, what this simply means is that AbbVie has negotiated rebates with health plans that will put brand Vicodin on their formulary at a “generic” copay. Hat’s off to AbbVie and their marketing efforts. I think I’ve gotten more email about the status of brand “ Vicodin” as a generic than spam emails notifying me I’m soon to inherit a fortune if only I just click this link…. So what’s happening? According to my Inbox…. Come to think of it, 24 hours is probably best. Not to mention hubris the size of the Milky Way to think that somehow I know better than the One who designed the planets to begin with. But of course, that would involve a significant rearrangement of the solar system. ![]() ![]() Sometimes I think that an extra 6-8 hours per day would be just about right to get everything done. Part of it has to do with the busyness of life with 4 children (3 of whom are teenagers), family, church and whatnot. Part of that has to do with my new job (more on that in posts to come). I haven’t kept up with my weekend Pharma news as frequently as I used to. ![]()
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